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Research interest in combination blends like KLOW stems from the hypothesis that multi-pathway stimulation may be more relevant to complex tissue injury models than single-agent approaches, where one pathway is modulated while others remain unaddressed

It is not known whether cysteine plays a primary role in the regulation of ferroptosis, beyond serving as a substrate in GSH synthesis

To combat oxidative stress, iPSCs employ a sophisticated antioxidant defense system, including superoxide dismutase and glutathione peroxidase, which are essential for protecting cells from ROS-induced damage [100]

Multiple organ failure including sepsis-induced cardiac dysfunction seem to be the result of numerous factors as overwhelming inflammation and nitric oxide synthesis impairment associated with mitochondrial dysfunction and increased oxidative stress (Cecchini and Cecchini, 2020)